胆汁酸
BTP-胆汁酸及相关物质分析服务
胆汁酸，英文名是bile acids（BA），是胆汁的主要有机成分，是几种结构类似的类固醇酸的统称。按照来源分，胆汁酸可以分为初级胆汁酸和次级胆汁酸。初级胆汁酸由肝细胞直接合成，次级胆汁酸则是经历了肠道细菌的粉剂以及肠肝循环后形成的产物。胆酸、鹅脱氧胆酸、甘氨胆酸、牛磺胆酸、甘氨鹅脱氧胆酸、牛磺鹅脱氧胆酸，为初级胆汁酸。脱氧胆酸、石胆酸、甘氨脱氧胆酸、牛磺脱氧胆酸、甘氨石胆酸、牛磺石胆酸，为次级胆汁酸。
百泰派克公司采用ACQUITY UPLC/TripleQuad5500（Waters/AB Sciex） LC/MS/MS实现对超过90个胆汁酸及相关物质标准品，配合胆汁酸同位素标准品进行定量及定性分析，其中涉及到的95%的物质均使用标准品和同位素标准品定量，显著提高了定性定量的准确性。
BTP-可检测胆汁酸及相关物质
百泰派克的技术员们经过多年的技术积累，ACQUITY UPLC/TripleQuad5500（Waters/AB Sciex） LC/MS/MS实现对超过90个胆汁酸标准品，配合胆汁酸同位素标准品进行定量及定性分析：
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胆汁酸分析服务列表1 (50种物质，Bile acids) Quantification of unconjugated, taurine- and glycine-conjugated bile acids and bile acid synthesis precursors in human and rodent plasma/serum, bile, tissues, cells, cecal content and feces by UPLC-MRM/MS |
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| 1 | 12-Ketochenodeoxycholic acid |
| 2 | 12-Ketolithocholic acid |
| 3 | 3-Oxocholic acid |
| 4 | 6,7-Diketolithocholic acid |
| 5 | 7-Ketodeoxycholic acid |
| 6 | 7-Ketolithocholic acid |
| 7 | Allocholic acid |
| 8 | Alloisolithocholic acid |
| 9 | Apocholic acid |
| 10 | Chenodeoxycholic acid |
| 11 | Cholic acid |
| 12 | Dehydrocholic acid |
| 13 | Dehydrolithocholic acid |
| 14 | Deoxycholic acid |
| 15 | DHCA |
| 16 | Dioxolithocholic acid |
| 17 | Glycochenodeoxycholic acid |
| 18 | Glycocholic acid |
| 19 | Glycodehydrocholic acid |
| 20 | Glycodeoxycholic Acid |
| 21 | Glycohyocholic acid |
| 22 | Glycohyodeoxycholic acid |
| 23 | Glycolithocholic acid |
| 24 | Glycoursodeoxycholic acid |
| 25 | Hyodeoxycholic acid |
| 26 | Isodeoxycholic acid |
| 27 | Isolithocholic acid |
| 28 | Lithocholic acid |
| 29 | Murocholic acid |
| 30 | Norcholic acid |
| 31 | Nordeoxycholic acid |
| 32 | Norursodeoxycholic acid |
| 33 | Tauro-β-muricholic acid |
| 34 | Tauro-α-muricholic acid |
| 35 | Tauro-ω-muricholic acid |
| 36 | Taurochenodeoxycholic acid |
| 37 | Taurocholic Acid |
| 38 | Taurodehydrocholic acid |
| 39 | Taurodeoxycholic Acid |
| 40 | Taurohyocholic acid |
| 41 | Taurohyodeoxycholic acid |
| 42 | Taurolithocholic acid |
| 43 | Tauroursodeoxycholic Acid |
| 44 | THCA |
| 45 | Ursocholic Acid |
| 46 | Ursodeoxycholic acid |
| 47 | α-Muricholic acid |
| 48 | β-Muricholic acid |
| 49 | λ-Muricholic acid (hyocholic acid) |
| 50 | ω-Muricholic acid |
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胆汁酸分析服务列表2 (66种物质，Bile acids) Quantitation of 50 compounds in bile acids analysis I (above) and 16 bile acid sulfates and glucuronides in plasma/serum and urine by UPLC-MRM/MR |
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| 1 | 12-Ketochenodeoxycholic acid |
| 2 | 12-Ketolithocholic acid |
| 3 | 3-Oxocholic acid |
| 4 | 6,7-Diketolithocholic acid |
| 5 | 7-Ketodeoxycholic acid |
| 6 | 7-Ketolithocholic acid |
| 7 | Allocholic acid |
| 8 | Alloisolithocholic acid |
| 9 | Apocholic acid |
| 10 | Chenodeoxycholic acid |
| 11 | Chenodeoxycholic acid 24-β-D-glucuronide |
| 12 | Chenodeoxycholic acid-3-glucuronide |
| 13 | Cholic acid |
| 14 | Cholic acid 3-sulfate |
| 15 | Dehydrocholic acid |
| 16 | Dehydrolithocholic acid |
| 17 | Deoxycholic acid |
| 18 | Deoxycholic acid - 3- glucuronide |
| 19 | Deoxycholic acid 3-sulfate |
| 20 | DHCA |
| 21 | Dioxolithocholic acid |
| 22 | Glycochenodeoxycholic acid |
| 23 | Glycochenodeoxycholic acid 3-sulfate |
| 24 | Glycocholic acid |
| 25 | Glycocholic acid 3-sulfate |
| 26 | Glycodehydrocholic acid |
| 27 | Glycodeoxycholic Acid |
| 28 | Glycodeoxycholic acid 3-sulfate |
| 29 | Glycohyocholic acid |
| 30 | Glycohyodeoxycholic acid |
| 31 | Glycolithocholic acid |
| 32 | Glycolithocholic acid 3-sulfate |
| 33 | Glycoursodeoxycholic acid |
| 34 | Hyodeoxycholic acid |
| 35 | Isodeoxycholic acid |
| 36 | Isolithocholic acid |
| 37 | Lithocholic acid |
| 38 | Lithocholic acid 3-sulfate |
| 39 | Lithocholic acid-24-glucuronide |
| 40 | Lithocholic acid-3-glucuronide |
| 41 | Murocholic acid |
| 42 | Norcholic acid |
| 43 | Nordeoxycholic acid |
| 44 | Norursodeoxycholic acid |
| 45 | Tauro-β-muricholic acid |
| 46 | Tauro-α-muricholic acid |
| 47 | Tauro-ω-muricholic acid |
| 48 | Taurochenodeoxycholic acid |
| 49 | Taurochenodeoxycholic acid 3-sulfate |
| 50 | Taurocholic Acid |
| 51 | Taurodehydrocholic acid |
| 52 | Taurodeoxycholic Acid |
| 53 | Taurodeoxycholic acid 3-sulfate |
| 54 | Taurohyocholic acid |
| 55 | Taurohyodeoxycholic acid |
| 56 | Taurolithocholic acid |
| 57 | Taurolithocholic acid 3-sulfate |
| 58 | Tauroursodeoxycholic Acid |
| 59 | Tauroursodeoxycholic acid 3-sulfate |
| 60 | THCA |
| 61 | Ursocholic Acid |
| 62 | Ursodeoxycholic acid |
| 63 | α-Muricholic acid |
| 64 | β-Muricholic acid |
| 65 | λ-Muricholic acid (hyocholic acid) |
| 66 | ω-Muricholic acid |
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胆汁酸分析服务列表3 (20种物质，Bile acids) Quantitation of 20 human and mouse specific bile acids kit |
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| 1 | Alpha-muricholic acid |
| 2 | Beta-muricholic acid |
| 3 | Chenodeoxycholic acid |
| 4 | Cholic acid |
| 5 | Deoxycholic acid |
| 6 | Glycochenodeoxycholic acid |
| 7 | Glycocholic acid |
| 8 | Glycodeoxycholic Acid |
| 9 | Glycolithocholic acid |
| 10 | Glycoursodeoxycholic acid |
| 11 | Hyodeoxycholic acid |
| 12 | Lithocholic acid |
| 13 | Omega-muricholic acid |
| 14 | Taurochenodeoxycholic acid |
| 15 | Taurocholic Acid |
| 16 | Taurodeoxycholic Acid |
| 17 | Taurolithocholic acid |
| 18 | Tauromuricholic acid (alpha + beta) |
| 19 | Tauroursodeoxycholic Acid |
| 20 | Ursodeoxycholic acid |
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胆汁酸分析服务列表4 (22种物质，Bile acids) Two-step solvent extraction. Supernatants are combined, dried, and re-suspended for LCMS separation by RPLC and measurement by ESI-QQQ MRM methods |
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| 1 | CA (Cholate)* |
| 2 | GCA (Glycocholate) |
| 3 | DCA (Deoxycholate)* |
| 4 | TLCA (Taurolithocholate)* |
| 5 | TCA (Taurocholate)* |
| 6 | CDCA (chenodeoxycholate)* |
| 7 | α-MCA (alpha-Murocholate)* |
| 8 | β-MCA (beta-Muricholate)* |
| 9 | ω-MCA (omega-Muricholate)* |
| 10 | GLCA (glycolithocholate) |
| 11 | TCDCA (taurochenodeoxycholate)* |
| 12 | TDCA (taurodeoxycholate)* |
| 13 | GHDCA (glycohyodeoxycholate) |
| 14 | GUDCA (glycoursodeoxycholate) |
| 15 | GCDCA (glycodeoxycholate) |
| 16 | GHCA (glycohyocholate) |
| 17 | HCA (hyocholic acid) |
| 18 | UDCA/HDCA (hyodeoxycholate)* |
| 19 | THDCA (taurohyodeoxycholate)/TUDCA (tauroursodeoxycholate) * |
| 20 | GDCA (glycodeoxycholate) |
| 21 | TaMCA (tauro-alpha-muricholate)/TbMCA(tauro-beta-muricholate)* |
| 22 | THCA Tauro-gamma-muricholate akataurohyocholate* |
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胆汁酸分析服务列表5 (Bile acids，28种物质) Identification & quantification of bile acids by LC-MS |
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| 1 | GCA |
| 2 | GCDCA |
| 3 | GUDCA |
| 4 | GDCA |
| 5 | GLCA |
| 6 | CA |
| 7 | CDCA |
| 8 | UDCA |
| 9 | DCA |
| 10 | LCA |
| 11 | GDCA-3S |
| 12 | GLCA-3S |
| 13 | CA-3S |
| 14 | CDCA-3S |
| 15 | UDCA-3S |
| 16 | GCA |
| 17 | GCA-3S |
| 18 | GCDCA-3S |
| 19 | DCA-3S |
| 20 | LCA-3S |
| 21 | TDHCA |
| 22 | TαMCA |
| 23 | TβMCA |
| 24 | TUDCA |
| 25 | THCA |
| 26 | THDCA |
| 27 | TCDCA |
| 28 | TLCA |
关于样品
血清、血浆、尿液、胆汁、胆酸；
细胞、肝脏、脑组织等动物组织及粪便等；
植物、酵母、微生物等
样本需求量：
血样、胆汁等：10微升
各种组织：10毫克
粪便等：10毫克
其它样本类型及用量请与百泰派克销售联系。
样品运输：以3-4公斤干冰挥发一天计算，请使用足量的干冰运输（建议尽量选用较大块的干冰，大块的干冰挥发较慢），并用泡沫盒封闭。并且尽量选用较快的邮递方式，以降低运输过程中样品降解的可能性。
中/英文项目报告
在技术报告中，百泰派克会为您提供详细的中英文双语版技术报告，报告包括：
1.实验步骤（中英文）
2.相关的质谱参数（中英文）
3.鉴定物质的定量或定量信息
4.质谱图片
5.原始数据
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